Week Ending July 12, 2021

World Hepatitis Day 2021 – Hepatitis can’t wait!
“World Hepatitis Day is observed each year on 28 July to raise awareness of viral hepatitis – infection of the liver, which, when chronic, can cause severe liver disease and liver cancer.”

HCV core antigen plays an important role in the fight against HCV as an alternative to HCV-RNA detection.
“To discuss the clinical significance of HCV-cAg testing in the diagnosis, activity determination, and monitoring of therapeutic effectiveness of HCV infection and its advantages compared with HCV-RNA and anti-HCV antibodies detection. By summarizing the published literature, the advantages and significance of HCV core antigen detection were sought.”

Eliminating hepatitis C in a rural Appalachian county: protocol for the Kentucky Viral Hepatitis Treatment Study (KeY Treat), a phase IV, single-arm, open-label trial of sofosbuvir/velpatasvir for the treatment of hepatitis C
“The overall goal of the Kentucky Viral Hepatitis Treatment Study (KeY Treat) is to eliminate hepatitis C transmission from a county in Appalachian Kentucky by removing the barriers to accessing hepatitis C virus (HCV) treatment.”

Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C
“This study sought to correlate 4 weeks of glecaprevir/pibrentasvir (GLE/PIB) treatment with and without ribavirin for patients with chronic hepatitis C and favorable baseline characteristics and to monitor the development of resistance-associated substitutions (RAS) and re-treatment outcomes if treatment failed.”

Hepatitis C vaccine could be rolled out within five years, says Nobel Prize winner who discovered virus
“A vaccine to protect against infection with hepatitis C could be in use within 5 years, says Professor Sir Michael Houghton, who won the Nobel Prize for Medicine and Physiology along with three other scientists for discovering the hepatitis C virus (HCV) in 1989. Sir Michael will discuss the development of a vaccine in a special presentation at this year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), held online this year.”