Week Ending August 15, 2022

Previously Treated NSCLC Has OS Gains With Tislelizumab Vs Docetaxel
“Updated data from the phase 3 RATIONALE-303 trial support tiselizumab over docetaxel for patients with non–small cell lung cancer receiving treatment in the second- or third-line setting.”

FDA Grants Accelerated Approval to Enhertu for Subgroup of Patients With Unresectable or Metastatic Non-Small Cell Lung Cancer
“The Food and Drug Administration (FDA) on Thursday granted an accelerated approval to Enhertu (fam-trastuzumab deruxtecan-nxki) for the treatment of adults with unresectable or metastatic non-small cell lung cancer whose tumors express human epidermal growth factor receptor 2 HER2 (ERBB2) mutations, according to a press release from the agency.”

Earlier Detection of Non-Small Cell Lung Cancer Needed for Younger Patients
“Advanced disease at diagnosis is more likely among younger patients with non-small cell lung cancer (NSCLC), according to data presented at the IASLC 2022 World Conference on Lung Cancer.”

Lung Cancer Screening Study Says Significant Disparities Persist Despite Expanded Eligibility
“While recent recommendations from the United States Preventive Services Task Force (USPSTF) to lower lung cancer screening thresholds significantly expanded eligibility for screening tests such as low-dose computed tomography (CT), differences in education, health-care insurance and proximity to health-care facilities continue to be key drivers of racial and socioeconomic disparities limiting access to appropriate preventive care.”

Informed Consent Forms for Lung Cancer Clinical Trials May Be a Barrier to Informed Participation
“Informed consent forms can be overwhelming for patients—they are written at a level that is too high for many patients, possibly impeding true informed consent, according to a report given by King-Kallimanis et al at the International Association for the Study of Lung Cancer (IASLC) 2022 World Conference on Lung Cancer (Abstract MA08.04).”

Research Suggests Air Pollution Be Included as Risk Factor for Nonsmoking Patients With Lung Cancer
“Researchers from Vancouver, British Columbia examined the effect of duration of past exposure to air pollution with lung cancer diagnosis in new research presented by Myers et al at the International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer 2022 (Abstract OA13.03).”

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers
“Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.”

Most Women With Lung Cancer Report Sexual Dysfunction
FRIDAY, Aug. 12, 2022 (HealthDay News) – “Sexual dysfunction is common in women with lung cancer, according to a study presented at the annual International Association for the Study of Lung Cancer World Conference on Lung Cancer, held from Aug. 6 to 9 in Vienna.”

Does Wildfire Smoke Cause Lung Cancer?
“And how does the risk compare with inhaling smoke from cigarettes?”

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Responses Shown With Amivantamab with lazeritinib and Chemo in EGFR+ NSCLC
“Melina E. Marmarelis, MD, assistant professor of Medicine at the Hospital of the University of Pennsylvania, reports the safety and efficacy data from the phase 1 CHRYSALIS-2 trial (NCT04077463).”