Week Ending October 17, 2022

Reaching for the gold standard of lung cancer screening
“Time is a precious resource in oncology. Detecting patients with cancer as early as possible gives clinicians the best chance to formulate a successful treatment response. Any delay in diagnosis or treatment can severely impact the options available to patients and healthcare professionals.”

Clinical Commentary: Testing and Targeting for NTRK Fusions in Non–Small Cell Lung Cancer
“The strategy of a broad molecular panel–based next-generation sequencing [NGS] approach minimizes tissue use and wastage.1 It would also identify where a driver mutation, such as an NTRK fusion, is a key component to improve patient care.”

Gender Differences in Quality of Life of Metastatic Lung Cancer Patients
“Gender aspects in lung cancer patients are a topic of growing interest. But little is known about gender aspects affecting the quality of life (QoL) for those with this life-threatening disease. The aim of the following study was to investigate how gender differences affect QoL in metastatic lung cancer patients.”

Adherence to Annual Follow-Up Lung Cancer Screening Low
“Adherence to annual screening among persons screened and entered into the American College of Radiology Lung Cancer Screening Registry (LCSR) is low, according to a study published online Oct. 11 in the Annals of Internal Medicine.”

New gene target for small-cell lung cancer discovered
“Scientists from Northwestern Medicine, US, have identified and described a new gene that is responsible for activating an aggressive subtype of small-cell lung cancer, the P subtype, for which there is no current effective treatment. The study was recently published in Science Advances.”

Risk of lung cancer is higher for people with HIV
“People in their 40s living with HIV in the United States were at twice the risk of developing lung cancer compared to the rest of the population, while people with HIV in their 60s were at 30% higher risk, a large study of cancer diagnoses between 2001 and 2016 in the United States has found.”

Lung Cancer Screening Can Reveal Lung-Related Comorbidities
“Lung cancer screening (LCS) using radiological imaging (ie, low dose computed tomography scan [LDCT]) offers a great opportunity to decrease death from lung cancer through early diagnosis. However, the clinical decision of screening is not straightforward since it should be tailored based on each patient’s risk for developing lung cancer and the expected benefits from early diagnosis. Studies have shown that lung-related comorbidities may influence a practitioner’s perception of lung cancer screening.”

Eligibility for Lung Cancer Screening Among Women With a Smoking History Undergoing Breast Cancer Screening
“In a single-center retrospective cohort study reported in JAMA Network Open, Titan et al identified the proportion of women with a history of smoking undergoing breast cancer screening with mammography who were eligible for low-dose computed tomography (CT) lung cancer screening, as well as the proportion who underwent lung cancer screening.”