Taletrectinib shows high response rates and safety in ROS1+ lung cancer patients
“The ROS1 tyrosine kinase inhibitor (TKI) taletrectinib demonstrated high overall and intracranial responses, and a favorable safety profile with low incidence of neurologic adverse events in TKI-naive and TKI-pretreated patients with ROS1+ non-small cell lung cancer (NSCLC).”
Patritumab Deruxtecan Demonstrated Statistically Significant Improvement in Progression-Free Survival Versus Doublet Chemotherapy in Patients with Locally Advanced or Metastatic EGFR-Mutated Non-Small Cell Lung Cancer in HERTHENA-Lung02 Phase 3 Trial
“BASKING RIDGE, N.J. & RAHWAY, N.J., September 17, 2024 – The HERTHENA-Lung02 phase 3 trial evaluating patritumab deruxtecan in patients with locally advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC) who received prior EGFR tyrosine kinase inhibitor (TKI) treatment met its primary endpoint of progression-free survival (PFS), demonstrating a statistically significant improvement versus platinum plus pemetrexed induction chemotherapy followed by pemetrexed maintenance chemotherapy. Overall survival (OS) data were immature at the time of the analysis and the trial will continue to further assess OS, a secondary endpoint.”
Early, virtual palliative care feasible for advanced lung cancer
“The delivery of early, virtual palliative care has similar effects on quality of life as in-person care in patients with advanced non-small cell lung cancer (NSCLC), according to a study published online Sept. 11 in the Journal of the American Medical Association.”
Hospitals begin offering breakthrough radiation therapy for metastatic cancer tumors
“Radiation is part of treatment for about half of cancer patients, yet many types of radiation therapy don’t reach all parts of the body, according to the American Cancer Society. Now a scientific breakthrough could change the future of the treatment and open up the option for others who may not have been able to get it.”
Perioperative Nivolumab Shows EFS Benefit vs Placebo in Resectable NSCLC
“Perioperative nivolumab (Opdivo) continued to display an event-free survival (EFS) benefit compared with placebo in patients with resectable non–small cell lung cancer (NSCLC), according to findings from an updated analysis of the phase 3 CheckMate 77T study (NCT04025879).”
GSK, iTeos lung cancer therapy outperforms Jemperli in mid-stage trial
“iTeos Therapeutics (NASDAQ:ITOS) announced Saturday that its experimental cancer doublet therapy developed with GSK (NYSE:GSK) outperformed the British drugmaker’s FDA-approved anti-PD-1 therapy dostarlimab, branded as Jemperli, in a mid-stage trial.
Rybrevant Plus Chemo Results in Superior Outcomes in EGFR-Mutant Advanced NSCLC
“Promising overall survival (OS) trends continued after longer follow-up with Rybrevant (amivantamab) plus chemotherapy vs chemotherapy alone in EGFR-mutant advanced non-small cell lung cancer (NSCLC) whose disease progressed on Tagrisso (osimertinib), according to findings from the second interim analysis of the MARIPOSA-2 trial.”
Clinical Benefit Improves With Relatlimab Combo in Recurrent NSCLC
“Clinical benefit improved among patients with stage IV or recurrent non–small cell lung cancer (NSCLC) who received relatlimab-rmbw plus nivolumab (Opdualag) plus chemotherapy vs those who were treated with nivolumab/chemotherapy only, according to data from the phase 2 RELATIVITY-104 study (NCT04623775) presented at the 2024 European Society for Medical Oncology Congress (ESMO).”
Zipalertinib Shows Promise in Heavily Pretreated EGFR Exon 20-Mutated NSCLC
“Treatment with zipalertinib appeared to be well tolerated with a manageable safety profile in heavily pretreated patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations who progressed on or after amivantamab (Rybrevant), according to data from module C of the phase 2b REZILIENT1 trial (NCT04036682) presented at ESMO Congress 2024.”
No DFS Benefit Seen With Adjuvant Durvalumab Across NSCLC PD-L1 Subgroups
“Disease-free survival (DFS) did not improve when adjuvant durvalumab (Imfinzi) was administered following complete resection and optional chemotherapy compared with placebo in patients with EGFR- or ALK-negative non–small cell lung cancer (NSCLC), regardless of PD-L1 expression, according to results from the phase 3 BR.31 trial (NCT02273375) presented at the 2024 European Society of Medical Oncology (ESMO) Congress.”
