Lung Cancer Weekly News

Unexpected findings on lung cancer CT scans may point to other non-lung cancers, study finds
“Because CT scans capture areas of the body beyond the lungs, doctors often see abnormalities that might indicate cancer in other parts of the body, including the kidneys, liver and lymph nodes. For the new study, the researchers focused on certain types of these abnormalities and found that people with these findings were more likely to be diagnosed with a cancer outside of the lungs (extrapulmonary) within a year of screening.”

Targeted Therapy Improves Long-Term Outcomes for Patients with Rare Mutations Driving Lung Cancer
“In some non-small cell lung cancers (NSCLCs), changes to the RET gene (known as RET fusions) can drive tumor growth. In a phase 1/2 clinical study with a 42-month-long follow-up period, researchers from Mass General Brigham Cancer Institute evaluated the long-term efficacy and safety of the FDA-approved drug pralsetinib, which targets RET. Investigators found that treatment led to durable responses with manageable safety profiles in 281 patients with advanced or metastatic RET fusion-positive NSCLCs. Results are published in Journal of Clinical Oncology”

Much Ado About Nothing? Time of Day May Not Matter for Immunotherapy in Lung Cancer
“The time of day when immunotherapy is administered to patients with lung cancer does not appear to affect overall survival, according to investigators from the ETOP-Roche i-TIMES study. The results, presented at the 2026 European Lung Cancer Congress in Copenhagen, Denmark, contradict those from the recently published LungTIME-C01 study. As reported by Oncology News Central, that study indicated that among patients with non-small cell lung cancer (NSCLC) without known targetable mutations, immune checkpoint inhibitor (ICI) infusions administered earlier in the day were associated with significantly better survival outcomes compared with infusions delivered in the midafternoon or later.”

Ai Predicts Chemotherapy Response in Lung Cancer Patients
“RT’s Three Key Takeaways: Predictive AI Tool: Researchers developed a tool called PhenopyCell that uses artificial intelligence to predict if patients with extensive-stage small cell lung cancer will respond to platinum-based chemotherapy before treatment begins. No Additional Biopsies: The system analyzes existing pathology slides from diagnostic biopsies, eliminating the need for further procedures, tissue collection, or added costs for patients. Immune Cell Organization: The tool identifies organized groups of immune cells surrounding tumor clusters as a biological marker for better treatment outcomes, which is not visible through manual analysis.”

Humanetics Corporation Announces Investigator-Initiated Phase 2 Trial in Patients with Non-Small Cell Lung Cancer and Underlying Interstitial Lung Disease
“MINNEAPOLIS, March 31, 2026–(BUSINESS WIRE)–Humanetics Corporation (Humanetics) announced today the launch of a new investigator-initiated clinical trial (IIT) of BIO 300 Oral Suspension (BIO 300), led by Dr. Narek Shaverdian, Director of Thoracic Radiation Oncology at Memorial Sloan Kettering Cancer Center (MSK). This study is designed to evaluate the efficacy of BIO 300 in reducing the toxicity of thoracic radiation therapy in patients with non-small cell lung cancer (NSCLC) and concomitant interstitial lung disease (ILD), compared to historical results. The trial will enroll approximately 24 participants at MSK in New York.”

“Another Negative Study”: Phase 3 Failure for Lung Cancer Combo
“It is a disappointing but all-too-familiar story: A drug combination that showed promise in phase 2 trials failed to meet its primary survival endpoint in a phase 3 study. The combination in question this time is the investigational ATR kinase inhibitor ceralasertib plus durvalumab (Imfinzi) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) without targetable genetic mutations who had disease progression on or after an immune checkpoint inhibitor and platinum-based chemotherapy.”

Mount Sinai Study Finds Lung Cancer Surgery Safe for Many Patients Over 80
“New York, NY (April 02, 2026)  Researchers at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center have found that adults aged 80 and older with early-stage lung cancer can safely undergo surgery and achieve outcomes comparable to younger patients, challenging longstanding assumptions about age and cancer treatment.”

Molecular phenotypes stratify small cell lung cancer for targeted therapy and immunotherapy
“This study identified three distinct SCLC phenotypes with unique therapeutic vulnerabilities. An ANXA1High subset within the immune-rich infiltrated phenotype showed ICI resistance, offering new strategies to enhance ICI efficacy.”

Even after a clear scan, smokers face an elevated lung cancer risk
“Key Takeaways: Long-term incidence after a negative LDCT was nontrivial, with 76 lung cancers detected, reinforcing that baseline negativity is not synonymous with durable low risk. Smoking exposure drove subsequent risk, with ~3-fold higher incidence in ever-smokers and clinically meaningful inflection around ≥20 pack-years.”

Subcutaneous Amivantamab is a ‘Way to Move Forward’ in EGFR+ NSCLC Care
“In a conversation with CancerNetwork®, Nicolas Girard, MD, PhD, detailed the results and clinical implications of the PALOMA-2 trial (NCT05498428), evaluating subcutaneous amivantamab (Rybrevant Faspro) in combination with lazertinib (Lazcluze) for patients with advanced non–small cell lung cancer (NSCLC) harboring EGFR mutations. According to data that he and colleagues presented in a poster session at the 2026 European Lung Cancer Congress, treatment with subcutaneous amivantamab demonstrated consistent efficacy compared with the agent’s intravenous formulation, while exhibiting the added tolerability and convenience benefits of subcutaneous administration.”

This Little-Known Japanese Fruit Could Help Stop Lung Cancer Before It Starts
“One unexpected candidate is a small fruit known as “Sarunashi” (Actinidia arguta), commonly referred to as the kiwiberry, which is being studied by researchers at Okayama University. In a study published in the journal Genes and Environment, the team found that juice from the fruit reduced lung tumor formation in mice exposed to NNK, a tobacco-related carcinogen. The juice also lowered the number of tumor nodules in the lungs, while one of its best-known compounds, isoquercetin (isoQ), showed protective effects of its own.”

Researchers find way to treat lung cancer and associated muscle wasting at the same time
“The study, published in the Journal of Controlled Release, involves lipid nanoparticles delivering therapeutic genetic material to lung tumors. In a mouse model, scientists led by Oleh Taraula and Yoon Tae Goo of the OSU College of Pharmacy showed that a type of nanocarrier loaded with follistatin messenger RNA is able to accumulate in tumors. Once there, the mRNA triggers cells to produce the follistatin protein, which plays a key role both in inhibiting tumors and promoting muscle tissue growth.”

Next-generation therapies to outsmart drug-resistant lung cancer
“The Gray Lab is developing next-gen therapies, including protein degraders and “dual-grip” inhibitors, to overcome drug resistance in lung cancer.”

PFOS, PFHA, Mono-Iso-Nonyl-Phthalate Can Predict Lung Cancer Mortality
“Researchers observed associations for higher circulating levels of PFOS, PFHA, and mono-iso-nonyl-phthalate with an increased risk for lung cancer death, but not with lung cancer incidence.”

Embryonic proteins reactivated in lung tumors may drive faster growth
“Researchers have uncovered how proteins normally active only before birth can drive aggressive lung cancer, opening new avenues for future treatments. The study found that more aggressive lung cancers switch on a pair of embryonic proteins (proteins not usually found in healthy adult cells), resulting in poorer patient outcomes.”

VATS vs Open Lobectomy in Early-Stage Lung Cancer: Survival Meta-Analysis Shows Overall Survival Benefit
“A new individual patient data meta-analysis provides the strongest answer to date. By pooling patient-level data from all eligible randomized trials, the investigators found that VATS lobectomy was associated with a 21% reduction in the risk of death compared with open lobectomy, with no compromise in disease-free survival (Harris et al., 2026). These results strengthen the scientific rationale for prioritizing VATS when technically feasible in patients with early-stage NSCLC.”

AI-driven technology does not speed up lung cancer diagnosis
“The LungIMPACT trial, the largest randomised trial of its kind and led from UCLH, ran across five NHS trusts in England and found no significant reduction in the time from X-ray to cancer diagnosis when AI flagged abnormal scans so that a radiologist could prioritise these for early review. The study, published today in Nature Medicine, only tested the impact of AI prioritisation and did not change the usual care pathway.”

Barry Manilow Details Lung Cancer Diagnosis and Treatment, Says It ‘Made Me Take Stock of My Life’ at 82 (Exclusive)
““You just don’t even think about [how fragile life is]. And suddenly, you have lung cancer. But I’m still here. I’m not all here; there’s part of me that isn’t here — they took out a part of me, and now I’ve got to figure out, ‘What do I do?’” Manilow says.”

Sunvozertinib Monotherapy Bests Platinum-Doublet Chemotherapy in EGFR Exon 20+ NSCLC
“Key Takeaways: Phase 3 WU-KONG28 randomized treatment-naïve stage IIIB/IIIC/IV nonsquamous NSCLC with confirmed EGFR exon 20 insertions to sunvozertinib 300 mg daily or carboplatin/pemetrexed ± pemetrexed maintenance. Blinded independent central review–assessed PFS per RECIST 1.1 was the primary end point, and overall survival was a key secondary end point in this confirmatory global program.”

Acute and Lifelong Exercise Modulate the Tumorigenic Potential of Human Lung Cancer Cells and Their Susceptibility to Cisplatin
“Significantly, we showed, for the first time, that lifelong exercise increased susceptibility to a chemotherapy agent (cisplatin), which may contribute to the decreased cancer mortality rates found among those who exercise regularly. Similar to the cellular effects, changes to serum cytokine levels – several of them linked to the senescence-associated secretory phenotype – depended on whether serum was conditioned by acute or by chronic exercise.”

Scientists discover why this deadly lung cancer keeps coming back
“Small cell lung cancer (SCLC) is among the most aggressive types of lung cancer, with a five-year survival rate of just five percent. Although it often responds well to chemotherapy at first, that success is usually short lived. Most patients experience a relapse, followed by rapid disease progression. Because of this pattern, understanding the biology behind SCLC is critical for extending treatment benefits, preventing relapse, and improving long term outcomes.”

Researchers identify genes for predicting lung cancer recurrence
“Researchers from Boston University Chobanian & Avedisian School of Medicine believe they have, for the first time, identified genes whose activity changes in lung tumors with vascular invasion. Additionally, they also discovered that they could detect these changes in small pieces of the tumor collected during a presurgical biopsy procedure.”

First-in-Class Investigational Drug KRAS G12D Degrader Shows Promise in Lung and Pancreatic Cancers
“Results from the trial were published in the New England Journal of Medicine, in March 2026. The study demonstrated benefit and safety in both lung and pancreatic cancers that had gotten worse on prior treatments. About a third of the patients with metastatic lung cancer responded to setidegrasib with encouraging durability, which means the length of time the drug stays effective. About 60% of the lung cancer patients were alive after one year.”

Nucleosome Liquid Biopsy Shows Promise for Lung Cancer Risk Stratification
“The poster presentation highlighted the use of Volition’s Nu.Q Cancer assays, which measure H3K27Me3-nucleosome levels from a simple blood draw, to predict recurrence-free and overall survival outcomes in lung cancer patients before surgery.”

Lung Cancer Patients Can Safely Receive Half the Usual Radiation Dose — in Just One Treatment
“6-year Roswell Park study shows shorter, lower-dose approach works just as well as longer course of treatment.”

Low-Dose CT Screening Reduces Lung Cancer–Specific Mortality
“The use of low-dose CT screening correlated with lower lung cancer–specific mortality in a non–risk-based lung cancer population, according to findings from the Lung-Care Project (NCT04938804) presented at the 2026 European Lung Cancer Congress.”

Adding Chemo to Osimertinib Doubles PFS in EGFR-Mutated NSCLC With TP53 Mutations
““These findings provide key evidence to support a molecular risk-guided individualized treatment strategy for EGFR-mutated non-small cell lung cancer,” Dr. Yang said during a proffered paper session (Abstract 20).”

Can marijuana cause lung cancer?
“As more states legalize marijuana, many people might be wondering if that means it is safe to use. While smoking tobacco is a known and well-studied cause of lung cancer, linking marijuana to cancer is more complicated, says Brooks Udelsman, MD, a thoracic surgeon with USC Surgery, part of Keck Medicine of USC.”

Hernexeos Shows Strong Responses in HER2 Non-Small Cell Lung Cancer
“Researchers reported at the 2026 European Lung Cancer Congress that Hernexeos (zongertinib) led to high response rates and disease control in patients with advanced HER2-mutant non–small cell lung cancer (NSCLC), including those with active brain metastases, addressing an unmet need for targeted first-line treatment options in this population.”

Vaping Likely Causes Cancer, Major Study Finds
“Nicotine vaping is likely to cause lung and oral cancers, a comprehensive review of more than 100 studies has concluded. According to the analysis, human and animal studies, as well as cell experiments looking at the effects of chemicals found in vape liquid, all point toward carcinogenicity. Those studies, published since 2017, record “increasing concern”, the researchers report.”

Nivolumab-Based Treatment Yields Long-Term Survival in Resectable NSCLC
“Perioperative nivolumab (Opdivo)-based treatment demonstrated long-term survival among patients with resectable stage IIA to IIIA non–small cell lung cancer (NSCLC), especially among those with a pathological complete response (pCR), according to findings from a phase 2 trial (NCT04015778) presented in a poster session at the 2026 European Lung Cancer Congress.”

Early diagnosis and local solutions are critical to combat lung cancer
“Opinion: Despite advances in prevention and treatment, lung cancer remains the world’s deadliest cancer largely because it is often detected too late. Strengthening local diagnostic capacity is one of the most effective ways to reduce the global burden of lung cancer.”

A video summary of the DeLLphi-301 study: tarlatamab as a treatment option for small cell lung cancer
“Small cell lung cancer (SCLC) is a very fast-growing lung cancer with few treatment options when standard treatments fail. The DeLLphi-301 study tested a medicine called tarlatamab to see if it shrinks SCLC in patients who had received previous treatments for SCLC. Tarlatamab works by directing the immune system’s T cells to link to and attack cancer cells. The DeLLphi-301 study tested whether a 10 or 100 mg dose would shrink SCLC better and have fewer side effects. It also assessed whether a post-treatment monitoring period could be shortened without compromising safety.”

Blocking lipid production in healthy lung cells can reduce lung metastasis
“Leuven, 17 March, 2026 – Scientists from the VIB–KU Leuven Center for Cancer Biology, in collaboration with the Francis Crick Institute, have discovered how cancer cells can exploit healthy lung cells to support metastatic tumor growth in the lungs. In two complementary studies published in Nature Cell Biology and Cancer Discovery, they show that tumors use lipids produced by lung cells as signals, and that decreasing the lipid production of lung cells can decrease metastasis. The findings point to new therapeutic strategies that target lung cell lipid production, rather than cancer cells themselves, which may also help refine patient selection for ongoing clinical trials targeting this pathway.”

Surgery in Octogenarians With Early-Stage NSCLC: What This Prospective Study Shows About Safety, Survival, And Quality Of Life
“As populations age and lung cancer screening identifies more small, potentially curable tumors, clinicians are increasingly faced with a difficult question: should adults aged 80 years and older undergo lung cancer surgery when early-stage disease is found? Concerns about frailty, postoperative complications, and long-term recovery often influence treatment decisions, yet prospective evidence in this population has remained limited. A new cohort study now adds important data to this discussion, showing that surgery in octogenarians with early-stage NSCLC can be feasible, with favorable long-term outcomes in carefully selected patients (Gros et al., 2026).”

PM2.5, Population Density Linked to Increased Lung Cancer Mortality in China
“The incidence of lung cancer increased in China from 2010 to 2018, with particulate matter 2.5 (PM2.5), average annual temperature, population density, and total grain production significantly associated with mortality, according to study findings published in Respiratory Medicine.”

Freenome Reports Data for Multiomic Blood-Based Screening Test for Lung Cancer
“BRISBANE, Calif., March 18, 2026 /PRNewswire/ — Freenome, an early cancer detection company developing blood-based screening tests, today announced initial development data for its investigational lung cancer screening test. The data demonstrate the potential of a multiomics approach that combines DNA methylation analysis and protein markers to detect lung cancer in high-risk individuals. Freenome investigators will present the data at next month’s AACR Annual Meeting in San Diego.”

VALOR Trial: Comparing SBRT with Surgery in Early Non-Small Cell Lung Cancer
“VALOR  Trial randomized clinical trial designed to compare lung cancer surgery with stereotactic body radiation therapy (SBRT) in patients with operable early-stage non-small cell lung cancer (NSCLC). Because both approaches are potentially curative, ensuring that treatment is delivered exactly according to protocol is essential for patient safety and for the scientific validity of the study. In this report, investigators described the development and early performance of a centralized quality assurance program for the SBRT arm of VALOR, focusing on the first 100 treated participants across the Veterans Health Administration.”

Delaying immunotherapy does not worsen survival in extensive-stage small cell lung cancer
“Key Takeaways: Real-world timing of atezolizumab or durvalumab initiation (cycle 1 vs cycle ≥2) showed comparable median PFS (~5.8 months) and OS (~10 months) in ES-SCLC. Delayed starts were frequently driven by hospitalization, with additional contributors including radiation scheduling, insurance authorization delays, and hepatic dysfunction impacting treatment sequencing.”

ASCO Updates Guidelines for Advanced NSCLC Without Driver Mutations
“Updates to the American Society of Clinical Oncology (ASCO) Living Guidelines for stage IV non-small cell lung cancer (NSCLC) without driver alterations reflect a maturing evidence base rather than sweeping change. As longer-term follow-up from landmark immunotherapy trials accumulates, clinicians are gaining a clearer picture of durability across PD-L1-defined subgroups while still navigating complex, subset-driven decision-making.”

When Small Cell Lung Cancer Hides from Immune Cells, Blood Vessels May Hold the Key
“BOSTON — Researchers at Dana-Farber Cancer Institute have uncovered why small cell lung cancer (SCLC) can stay largely out of reach of the immune system, even when the cancer cells themselves are vulnerable to immune attack. In the most common form of neuroendocrine SCLC, investigators found that tumor blood vessels can act like a gatekeeper, preventing natural killer (NK) cells from leaving the bloodstream and entering the tumor. When the researchers activated an immune “alarm” pathway called STING in the tumor’s vascular environment, NK cells were able to get into the tumor and kill cancer cells, with an even stronger effect when STING activation was combined with a DLL3-targeted CAR-NK cell therapy in preclinical models.”

How Much Is Enough? Ultra-Low Doses of Immunotherapy to Improve Access and Affordability
“The immunotherapy revolution has led to improved outcomes for patients with common solid tumors in wealthy countries, which, however, has bypassed many patients in low- and middle-income countries (LMICs) because of the unaffordable cost of treatments.”

Utility of Tissue-of-Origin Algorithms in Cases Diagnosed as Lung Squamous Cell Carcinoma
“Molecular profiling has enabled substantial advancements in diagnostics and clinical care, including increasingly precise tumor classification and targeted therapies. Nevertheless, there are areas of diagnostic ambiguity that remain challenging, even with all currently available approaches.”

SystImmune, Inc. to Present New iza-bren (izalontamab brengitecan) Data in Extensive Stage Small Cell Lung Cancer at ELCC 2026
“”The data being presented at ELCC highlight the continued clinical progress of iza-bren and its potential as a novel treatment approach for patients with difficult-to-treat lung cancers,” said Jonathan Cheng, M.D., Chief Medical Officer of SystImmune. “We are encouraged by the safety and efficacy signals observed with iza-bren in combination with serplulimab in treatment-naïve patients with extensive-stage small cell lung cancer. These findings support further exploration of iza-bren–based combinations in earlier lines of therapy as we work to expand therapeutic options for patients with aggressive lung malignancies.””

Study shows AI-assisted risk model for lung nodules is cost-effective
“Risk prediction software using artificial intelligence can help determine whether pulmonary nodules detected during lung cancer screening need to be biopsied.”

PFOS, PFHA, Mono-Iso-Nonyl-Phthalate Can Predict Lung Cancer Mortality
“HealthDay News — A model composed of perfluorooctanesulfonic acid (PFOS), perfluoroheptanoic acid (PFHA), and the plasticizer mono-iso-nonyl-phthalate can predict lung cancer mortality, according to a study published online March 4 in Clinical Cancer Research.”

Multidisciplinary Decision-Making and CNS-Penetrant Therapies Redefine Brain Metastases Management in Lung Cancer
“The growing availability of central nervous system (CNS)–penetrant targeted therapies is reshaping the management of brain metastases in select patients with lung cancer, challenging the long-standing priority of upfront local therapy, according to Laura Alder, MD.”

Biodesix Announces the Largest Lung Nodule Biomarker Clinical Validation Study Ever Published Supporting Earlier Lung Cancer Diagnosis
“LOUISVILLE, Colo., March 20, 2026 (GLOBE NEWSWIRE) — Biodesix, Inc. (Nasdaq: BDSX), a leading diagnostics solutions company, announced the publication of the largest lung nodule biomarker clinical validation study ever conducted. This milestone strengthens the clinical foundation for Nodify CDT® tests as a critical decision-support tool in the early detection of lung cancer, addressing a significant unmet need in the management of the millions of lung nodules detected annually in the United States.”

Why Lung Cancer is Now “12 Different Diseases”
“Modern medical advancements have radically transformed our understanding of lung cancer. Rather than viewing it as a singular condition, oncology now treats it as a collection of distinct molecular subtypes. This evolution in targeted therapy presents a significant challenge: the sheer volume of complex information required to match specific molecular profiles with the appropriate treatment stages is staggering. Keeping pace with this rapidly shifting landscape demands a new level of expertise to ensure patients receive the most effective care.”

Bill to require radon mitigation looks to decrease lung cancer risks
“400 Iowans die annually from lung cancer caused by radon exposure results.”

Why lung cancer belongs in the women’s health conversation
“Cancer mortality in the United States has steadily declined for more than three decades, with millions of lives saved through smoking cessation, earlier detection, and improved treatment. But the epidemiology of lung cancer is shifting in ways we can no longer ignore. Beginning in 2021, lung cancer incidence in women under 65 surpassed that of men for the first time. The progress we are making in this disease is real, but it doesn’t tell the whole story.”

Common p53 genetic mutation reveals Achilles’ heel in lung cancer
“A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA replication in cancer cells. The new findings published in Cell Death & Differentiation support an innovative framework for how targeting this new pathway could help to stop the replication of lung tumor cells and thwart tumor growth.”

FDA Cites Manufacturing Issues in Lung Cancer Drug Rejection
“The U.S. Food and Drug Administration (FDA) declined the approval of retifanlimab-dlwr (Zynyz) for non-small cell lung cancer (NSCLC) over concerns about the PD-1 inhibitor’s manufacturing plant.”

Picture Health publishes study findings for lung cancer AI biomarker
“Researchers found that QVT scores at the start of treatment independently predicted survival outcomes, and that early decreases in QVT scores during treatment appeared sooner than traditional tumor response measures, Picture Health said.”

Managing Myelosuppression in Small Cell Lung Cancer: The Case for Trilaciclib
“Trilaciclib protects bone marrow before SCLC chemotherapy, sharply reducing neutropenia, anemia, and thrombocytopenia, improving fatigue and keeping treatment on schedule without weakening tumor kill.”

A Bad Case of COVID or Flu May Raise Lung Cancer Risk Years Later
“New research from UVA Health’s Beirne B. Carter Center for Immunology Research and the UVA Comprehensive Cancer Center suggests that severe cases of COVID-19 and influenza may create conditions in the lungs that make cancer more likely to develop later. The study also found that vaccination appears to prevent these harmful effects.”

Tobacco tax, pesticide monitoring could help address Iowa’s high cancer rates, researchers say
“These UI researchers and staff presented preliminary information gathered in a yearlong research project conducted through a UI partnership with the Iowa Department of Health and Human Services. Lawmakers had approved $1 million in funding last year for the project, seeking to identify the factors leading to Iowa’s ranking as having the second-highest rate of new cancer cases in the country, and as one of only two states with a rising rate of new cancers in 2025.”

The telltale lung: A new clue for early-stage lung cancer
“Led by oncologist and cancer researcher Dr. Frank Weinberg, the scientists looked at lung cells and fluids from 20 cancer patients. They noticed the patients’ lungs shared a unique combination of molecules. That combination, they realized, is a telltale warning sign that can help them detect, treat and, perhaps, even prevent lung cancer in its earliest stages.”

Gaps in Lung Cancer Treatment Persist, Yale Study Finds
“In recent decades, lung cancer treatment has been transformed—new surgeries, new radiation techniques, and dramatically improved outcomes. But according to new research from Yale, published in JAMA Network Open, one thing has barely changed: who receives curative care.”

FDA approves HERNEXEOS®, the first targeted therapy for adults with HER2-mutant advanced NSCLC as an initial treatment option
“HERNEXEOS® (zongertinib tablets) approved based on an objective response rate of 76% (N=72) as demonstrated in the Beamion LUNG-1 clinical trial. Accelerated approval follows Breakthrough Therapy Designation and prior FDA approval for previously treated patients in August 2025”

New study identifies growth hormone receptor as possible target to improve lung cancer treatment
“Researchers at Ohio University have discovered what may be a new way to fight lung cancer that is resistant to other treatments. The study, led by Goll-Ohio Eminent Scholar and distinguished professor John J. Kopchick, Ph.D., and his graduate student Arshad Ahmad at the Heritage College of Osteopathic Medicine, found that blocking the growth hormone receptor may help make lung cancer treatments more effective.”

AI tool could help predict side effects from lung cancer treatment
“The study, published in Reports of Practical Oncology and Radiotherapy, focuses on the lung’s natural subunits, called lobes. Rather than treating the lung as a single organ, researchers have found that the radiation dose administered to specific lobes matters. Damage to certain lobes, particularly the lower ones, raises the risk of lung toxicity and side effects.”

Gut Microbiome as a Predictor of Dual Checkpoint Inhibition Benefit in Non–Small Cell Lung Cancer
“Dual immune checkpoint inhibition with ipilimumab plus nivolumab (I–N) represents an established therapeutic strategy for advanced non–small cell lung cancer (NSCLC), capable of producing durable responses even in tumors with low PD-L1 expression. However, clinical benefit remains restricted to a subset of patients, and the optimal integration of chemotherapy into dual immunotherapy regimens continues to represent a major unresolved clinical challenge.”

Do the “oldest old” non-small cell lung cancer patients experience the worst outcomes after radiotherapy?
“Conclusion: Patients with NSCLC aged >=80 years show no statistically significant differences in terms of faring even better after receiving radiotherapy for NSCLC with their younger counterparts. However, older patients with NSCLC had a trend of higher rates of severe thrombocytopenia and longer progression-free survival than younger patients with NSCLC. We could not verify our hypothesis; however, curative lung radiotherapy can be an effective and safe treatment for patients aged >=80 years.”

Lung Cancer Research Foundation Launches Small Cell Lung Cancer Grants in Collaboration with AstraZeneca
“NEW YORK, Feb. 24, 2026 /PRNewswire/ — The Lung Cancer Research Foundation (LCRF) announces a new research collaboration with AstraZeneca aimed at driving progress in small cell lung cancer (SCLC) with two grant awards, 2026 LCRF | AstraZeneca Research Award on Strategies Towards Improving the Treatment of Small Cell Lung Cancer and 2026 LCRF | AstraZeneca Research Award on Strategies Using Patient Advocacy to Improve Outcomes in Small Cell Lung Cancer.”

ACS Report Shows 5-Year Survival for All Cancers Combined Has Reached 70%
“New data published by Siegel et al in the American Cancer Society’s (ACS) Cancer Statistics, 2026 report show that, for the first time, the 5-year survival rate for all cancers combined has reached 70% for individuals diagnosed during 2015 to 2021 in the United States. In addition, those diagnosed with high-mortality cancers and advanced diagnoses experienced the largest gains in survival. Still, in the United States, cancer remains the second-leading cause of death overall and the leading cause of death among those younger than age 85.”

Explainable active reinforcement deep learning improves lung cancer detection from CT images
“Lung cancer remains a global health challenge that requires early and accurate diagnosis through medical imaging analysis. This study introduces ARXAF-Net framework which integrates Active Reinforcement deep leaning with strategic feature engineering, selection, advanced classification techniques with Explainable AI.”

Air pollution and lung cancer: an investigation of county-level residual incidence rates with smoking eliminated
“Smoking is the leading cause of lung cancer and this can make it difficult to focus public attention on other preventable causes, like air pollution. To provide easily understandable quantitative information on the relative importance of smoking and air pollution as contributors to lung cancer, we used a two-stage regression method to simulate what would happen to county-level lung cancer rates if smoking were completely eliminated.”

FDA Grants Second Approval under the National Priority Voucher Pilot Program
“The U.S. Food and Drug Administration today issued an approval for the lung cancer drug Hernexeos (zongertinib) as a part of the new Commissioner’s National Priority Voucher (CNPV) pilot program. In the clinical trial data submitted to the agency, a remarkable 76% of previously untreated patients had a substantial decrease in tumor size, representing a significant improvement from the current standard of care whereby 30-45% of patients are typically expected to demonstrate this response.”

Why Lung Cancer Patients Feel Worse at Night: Sleep, Anxiety and Breathing Explained
“Night changes the perceptual landscape of illness. During the day, lung cancer patients are embedded in structure: appointments, imaging, multidisciplinary discussions, treatment planning. Cognitive bandwidth is occupied. Clinical reassurance is accessible. At night, this scaffolding dissolves. What remains is interoception — the awareness of internal bodily signals — and unmoderated cognition.”

How EPA’s New Rollbacks Could Fuel Toxic Pollution Nationwide
“Two years ago, we celebrated a huge victory for public health when the U.S. Environmental Protection Agency (EPA) announced stronger rules to clean up power plant pollution. Unfortunately, since then the regulatory landscape has changed dramatically, with drastic consequences for air quality and lung health.”

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Examining Equity Gaps in Immune Checkpoint Inhibitor Trials for NSCLC
“Key Takeaways: Persistent underrepresentation of women, older adults, and Black patients in NSCLC immune checkpoint inhibitor trials limits the generalizability of evidence used to guide clinical decision-making. Disparities in trial enrollment may mask clinically meaningful differences in immunotherapy response and survival across age, sex, and racial groups. Improving equitable trial access, community engagement, and diversity among clinical investigators is essential to ensure NSCLC treatment guidelines reflect real-world patient populations.”

Nivolumab plus ipilimumab with chemotherapy as first-line treatment of patients with metastatic non-small-cell lung cancer: final, 6-year outcomes from CheckMate 9LA
“This analysis highlights the durability of first-line nivolumab plus ipilimumab with limited chemotherapy in metastatic NSCLC, demonstrating sustained overall survival and long-term response across PD-L1 expression levels and histologies. The findings reinforce that the survival benefit observed in CheckMate 9LA is maintained in broader clinical practice, including patients with traditionally poorer prognostic features such as PD-L1–negative and squamous disease.”

FDA Approves Monthly Dosing for Subcutaneous Amivantamab in EGFR-Mutated NSCLC
“The U.S. Food and Drug Administration has approved a once-monthly dosing schedule for frontline amivantamab and hyaluronidase-lpuj (Rybrevant Faspro), the subcutaneous formulation of the bispecific antibody, for adults with EGFR-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC). The new dosing schedule applies to all of amivantamab’s previously approved indications.”

Immunotherapy Combo Fails to Improve Survival in Limited-Stage Small Cell Lung Cancer
“Adding atezolizumab (Tecentriq) to concurrent chemoradiation therapy (CRT) did not improve survival for patients with limited-stage small cell lung cancer (LS-SCLC), according to a recent clinical trial. However, experts say that the results add clarity to treatment sequencing questions and reinforce the current standard of care, despite the negative findings.”

ASCO Updates First-Line Treatment for Stage 4 EGFR Lung Cancer
“These new guidelines, published in the Journal of Clinical Oncology, provide a roadmap for using newer combination therapies as the first treatment for patients whose cancer has certain mutations, such as those in the EGFR gene. By incorporating the latest data from 13 clinical studies, the expert panel aims to help patients with cancer and their healthcare teams choose the most effective treatment options based on the unique genetic signature of their tumor.”

‘A breath of fresh air’: UW chair of surgery’s push for early detection of America’s deadliest cancer
“Lung cancer fatalities exceeded the combined fatalities from colon, breast, and prostate cancer in 2014. And in 2010, 65 to 80% of adults with cervical, breast, prostate, and colorectal cancer were up to date on screenings, but lung cancer was not screened at all. Without early detection, the majority of cases are caught in later stages, when the chance of survival is less than 10%.”

This new blood test could detect cancer before it shows up on scans
“A new light-based sensor can spot incredibly tiny amounts of cancer biomarkers in blood, raising the possibility of earlier and simpler cancer detection. The technology merges DNA nanotechnology, CRISPR, and quantum dots to generate a clear signal from just a few molecules. In lung cancer tests, it worked even in real patient serum samples. Researchers hope it could eventually power portable blood tests for cancer and other diseases.”

Mayo Clinic study identifies mechanism behind immunotherapy resistance in lung cancer
“PHOENIX — Mayo Clinic researchers and collaborators have identified a previously unrecognized way lung tumors weaken the immune system, helping explain why many patients do not respond to immunotherapy and pointing to a potential new approach to make those treatments more effective. The study, published in Cancer Immunology Research, focuses on regulatory T cells, immune cells that normally keep the immune system from becoming overactive.”

Can We Afford the New Era of Lung Cancer Survival?
“Partitioned survival modeling estimated OS 66.1 vs 57.8 months and PFS 40.2 vs 31.8 months for durvalumab vs placebo, with substantially higher total costs.”

Does Lung Cancer Screening Have a Psychological Impact?
“Recipients of low-dose computed tomography (LDCT) screening for lung cancer experienced increased psychological distress, which can contribute to diminished quality of life, according to results from a recent study.”

The impact of obesity-related systemic inflammation on the efficacy, toxicity, and biomarkers of immune checkpoint inhibitors in lung cancer: from mechanisms to clinical management
“Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of lung cancer, yet the heterogeneity in their efficacy and toxicity among different patients remains a significant clinical challenge. Obesity, as a global epidemic associated with chronic low-grade systemic inflammation and complex immunometabolic disturbances, has been identified as a crucial regulatory factor in cancer immunotherapy response. This review aims to systematically and deeply explore the intricate network of interactions between obesity, lung cancer, and immunotherapy.”

Will Offering a Blood Test to Detect Lung Cancer Improve Screening Rates?
“Dr. Melinda Aldrich wants to boost screening rates to catch lung cancer earlier when it is more treatable.”

Tuberculosis, Chronic Bronchitis Linked to Lung Cancer Risk in Never-Smokers
“A literature search was performed in PubMed and Embase from inception to July 2025 for relevant studies that assessed associations between previous lung disease and LC risk in adults aged 18 years and older who had never smoked. The primary outcome was LC risk in populations with or without a history of TB, asthma, or CB.”

First ever inhalable gene therapy for cancer gets fast-tracked by FDA   
“A gene therapy that patients breathe in has been found to shrink lung tumours by inserting immune-boosting genes into surrounding cells”

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells
“Primary cilia are antenna‑like organelles on almost all human cells that sense and transduce extracellular cues into cellular response. Primary cilia have been reported to be implicated in drug resistance in several cancer types, but their roles in cellular response to epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) in non‑small cell lung cancer (NSCLC) are still not fully understood.”

Boots launches lung cancer early awareness scheme
“Signs will be placed around over-the-counter cold and flu management products advising patients to speak to a Macmillan-trained pharmacist if they have symptoms suggestive of lung cancer.”

UV-induced immune modulation in the lung niche slows cancer progression
“Ultraviolet radiation has a well-documented local immunosuppressive effect on the skin that can enhance subcutaneous tumor growth; however, its systemic impact on cancer progression in internal organs remains poorly understood. Here, we show that chronic UVB exposure after melanoma metastasis to the lung inhibits metastatic growth and modestly improves survival in mice.”

Lilly’s Retevmo (selpercatinib) delivers substantial event-free survival benefit as an adjuvant therapy in early-stage RET fusion-positive lung cancer
“INDIANAPOLIS, Feb. 16, 2026 /PRNewswire/ — Eli Lilly and Company (NYSE: LLY) today announced positive topline results from the Phase 3 LIBRETTO-432 clinical trial of Retevmo (selpercatinib) as adjuvant therapy versus placebo. The study met its primary endpoint, demonstrating a highly statistically significant and clinically meaningful improvement in investigator-assessed event-free survival (EFS) in patients with early-stage (II-IIIA) rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC).”

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Precision Oncology: Transforming Survival in Lung Cancer Brain Metastases
“The landscape of treating brain metastases—cancer that has spread to the brain—is undergoing a radical shift from a terminal prognosis to a manageable chronic condition. Manmeet Ahluwalia, MD, chief scientific officer at Baptist Health Miami Cancer Institute, highlights that while these diagnoses were once associated with a survival rate of only 6 to 12 months, modern innovations now allow many patients to live for 3 to 5 years or longer.”

FDA Issues 510(k) Clearance of AI-Powered Assessment for Lung Cancer on Low-Dose CT Scans
“The Food and Drug Administration (FDA) has granted 510(k) clearance for the AI-enabled eyonis® LCS software, which may facilitate earlier detection of lung cancer on low-dose computed tomography (CT) scans.”

‘Personal lives’ of lung cancer cells help predict response to treatment
“University of Queensland researchers who mapped cancer cell “neighborhoods” in the most common type of lung cancer have found cell metabolism plays a critical role in determining how lung cancer patients will respond to immunotherapy. Their results are published in Nature Communications.”

Two Decades of Data Reveal Mortality Patterns, Disparities in Lung Cancer and Diabetes
“Mortality associated with lung cancer among patients with diabetes has continued to rise in the United States over the past two decades, with persistent racial, geographic, and sex-based disparities, according to findings from a recent study. A team of researchers from Pakistan conducted the study and published the results in The Egyptian Journal of Bronchology. The investigators cited lung cancer and diabetes as “leading causes of death worldwide” and explained that it was important to evaluate associations between the conditions as they commonly coexist in older adults and can impact prognosis and survival, despite “very limited scientific data” about the correlation.”

American Lung Association Commends Passage of Bipartisan Health Funding
“Today, the House passed, and President Trump signed into law, critical funding for the Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH), ensuring continued investment in lifesaving public health and research programs.”

Photon-counting CT Outperforms Conventional CT in Lung Cancer Management
“In a prospective imaging study of 200 adults with lung cancer, photon-counting CT reduced radiation exposure, had fewer adverse reactions and provided higher image quality and better detection of malignant features compared with conventional CT. Results of the study were published in Radiology.”

How tumours trick the brain into shutting down cancer-fighting cells
“Lung cancer cells in mice can connect with nearby neurons to send a ‘shutdown’ signal to the brain that suppresses tumour-killing immune cells.”

Expanding Lymph Node Assessment Could Improve Lung Cancer Staging
“Lymph node assessment should be expanded in patients undergoing surgery for non-small-cell lung cancer (NSCLC) to more accurately detect hidden systemic disease, suggests research presented at the 2026 Society of Thoracic Surgeons Annual Meeting.”

Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models
“KRAS is a common oncogene that has become targetable with new therapies primarily being allele specific. Lung cancers with G12C and G12D mutations represent two of the most common KRAS-driven subsets, with approved therapies available for G12C. However, how distinct KRAS alleles differentially shape tumor biology and immune interactions and how this influences dependence on KRAS signaling and responses to KRAS inhibition are not well understood.”

Krystal Biotech Announces RMAT Designation Granted by FDA to KB707 for the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer
“PITTSBURGH, Feb. 09, 2026 (GLOBE NEWSWIRE) — Krystal Biotech, Inc. (the “Company”) (NASDAQ: KRYS) announced today that the United States Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation to KB707, the Company’s redosable immunotherapy designed to drive sustained, localized expression of interleukin-2 and interleukin-12 in the tumor microenvironment, for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC).”

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How Cancer Treatment Affects Lung Function in Survivorship
“Dr. Joshua Sabari explains how surgery, radiation and therapy may reduce lung capacity and shares steps survivors can take to protect breathing health.”

FDA Clears AI-Powered Software for Assessment of Incidental Lung Nodules on CT
“The Food and Drug Administration (FDA) has issued 510(k) clearance for the RevealAI-Lung software for the assessment of incidental lung nodules detected on CT. Validated on over 1,500 patients from a variety of cohorts, the RevealAI-Lung software enables one to click on a nodule and obtain a Malignancy Similarity Index (mSI™). Through proprietary analytics, the mSI score provides clinical insights that may facilitate earlier detection and reduce unnecessary procedures, according to RevealDx, the manufacturer of the software.”

Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial
“In summary, our study indicates that early ToD immunochemotherapy substantially improves PFS and OS and is associated with enhanced antitumor CD8+ T cell characteristics compared with late ToD treatment.”

Lightweight Neural Networks Improve Lung Cancer Diagnosis
“The findings highlight the potential of custom lightweight CNN architectures as efficient tools for histopathological image analysis. By offering a reproducible evaluation framework, this approach may be extended to larger datasets or adapted for future clinical diagnostic applications, supporting the integration of artificial intelligence into routine healthcare practice.”

Deep-Learning CT Biomarker Predicts Survival Better Than Traditional Measures in Immunotherapy-Treated Advanced NSCLC
“The investigators concluded, “Serial CTRS is an externally validated, fully automated, deep-learning, serial imaging–based biomarker that leverages routine CT scans from baseline and early-response follow-up to predict overall survival more effectively than RECIST and tumor volume change in immune checkpoint inhibitor–treated patients with advanced NSCLC. The automated design of Serial CTRS facilitates future integration into clinical practice and clinical trial workflows. With further validation across therapeutic modalities, Serial CTRS has the potential to enable more accurate, early treatment readouts in both clinical practice and clinical trial settings.””

POM121 O-GlcNAcylation facilitates bone metastasis in non-small cell lung cancer through enhanced c-MYC nuclear import and ECM reprogramming
“These findings establish the OGT-POM121-c-MYC-ECM axis as a potential diagnostic biomarker and a promising therapeutic target for NSCLC bone metastasis.”

NCCN NSCLC Guidelines Update Staging, Emphasize Molecular Testing
“The National Comprehensive Cancer Network’s (NCCN) newly updated non-small cell lung cancer (NSCLC) guidelines add sevabertinib as a treatment option for some patients with advanced disease, make datopotamab deruxtecan-dlink a preferred option for some patients in second line, and update staging guidelines to follow the American Joint Committee on Cancer (AJCC) 9th edition.”

Additional lymph node evaluation needed during surgery to accurately identify lung cancer spread
“Breakthrough research presented at the 2026 Society of Thoracic Surgeons Annual Meeting shows that additional lymph node evaluation is needed during surgery for non-small cell lung cancer (NSCLC) to accurately identify cancer spread.”

Pirfenidone Associated With Over 70% Lower Lung Cancer Risk in IPF
“Pirfenidone may reduce lung cancer risk in IPF by up to 76% in sensitivity analyses, though evidence is limited to observational East Asian studies.”

‘Staggering’: More than 60% of patients with lung cancer do not meet screening criteria
“Key takeaways: Lung cancer screening guidelines may exclude more than 60% of patients who develop the disease. Age-based screening could save more than 25,000 additional lives per year.”

Monoclonal Antibody May Transform Care for Certain NSCLC, Phase 3 Data Suggest
“Gotistobart reduced risk for death by nearly half compared with docetaxel in patients with metastatic squamous non-small cell lung cancer (NSCLC) who had progressed on PD-(L)1 inhibitors. These results are based on findings from stage 1 of the ongoing, multicenter, international, randomized controlled phase 3 PRESERVE-003 trial and were presented at the North America Conference on Lung Cancer (NACLC). Stage 1 is the dose-confirming part of the trial, and stage 2 is actively enrolling patients.”

NHS launches a single end-to-end lung cancer diagnostic pathway initiative with Optellum
“This is the first NHS programme to combine VNC’s AI-based lung nodule risk stratification with robotic-assisted bronchoscopy, streamlining the pathway from CT imaging to biopsy for patients with suspected lung cancer. With VNC’s AI, high-risk lung nodules on imaging are rapidly identified, and if tissue sampling is required, robotic-assisted bronchoscopy is then used to navigate to and biopsy hard-to-reach nodules as small as 6 mm. For many patients, this can potentially reduce months of uncertainty with a single targeted procedure.”

Foot on the gas: How RIT1 and YAP accelerate lung adenocarcinoma
“Mutations in the RIT1 gene have emerged as rare, yet recurrent drivers in several human cancers, including lung adenocarcinoma. RIT1 (Ras-like in all tissues) encodes a protein that helps cells respond to growth signals from their environment. It works a bit like a rechargeable battery: when it’s loaded with energy, it sends messages that tell a cell to grow or adapt, and once that energy is spent, the signal shuts off.”

Leptomeningeal Metastasis (LM) Clinical Trial Offers Treatment for Stage 4 Lung Cancer Patient
“Carlos Veras had been given months to live, when his stage 4 lung cancer spread to the fluid around his brain and spine. He’s alive two years later, thanks to a collaboration between neuro-oncologist Dr. Adrienne Boire, left, and computational biologist Dr. Dana Pe’er. After a decade of research, the scientists found a way to stop the cancer cells from surviving in the cerebrospinal fluid.”

Lung cancer survivors at risk for non-lung secondary cancer years after definitive therapy
“Key takeaways: Non-lung secondary cancers can develop in survivors of lung cancer years after completion of definitive therapy. Hereditary cancer syndrome and/or pathogenic germline variants were strongly associated with increased risk.”

Treatment adherence and clinical outcomes of osimertinib in minority patients with advanced EGFR mutated NSCLC
“In multivariable analyses, NHB patients experienced significantly worse overall survival compared with NHW patients, both in the overall cohort (Hazard ratio (HR) 1.83, 95% confidence interval (CI) 1.02–3.27) and in first-line osimertinib users (HR 3.42, 95% CI 1.48–7.88), despite similar adherence rates. Hispanic and Asian patients also showed trends toward inferior outcomes. These findings highlight survival disparities and underscore the need for inclusive trials and targeted strategies.”

Phytochemical Triad in Lung Cancer: Synergistic Mechanisms and Clinical Translation of Genistein, Piperine, and Resveratrol
“This review critically explores their synergistic effects while highlighting the challenges in translating these findings into clinical applications for lung cancer. By elucidating the underlying molecular mechanisms and therapeutic synergy, these natural compounds emerge as promising adjuncts for lung cancer therapy, warranting further mechanistic and clinical investigation.”

Osimertinib Dose Reduction Does Not Compromise OS in EGFR-Mutated Metastatic NSCLC
“Reducing osimertinib dose in the first-line treatment of EGFR-mutated metastatic non-small cell lung cancer (mNSCLC) patients due to the occurrence of adverse events has no impact on overall survival (OS), according to research published in Lung Cancer.”

Lung Cancer in the Incarcerated Population: A Narrative Review
“While the literature is limited, existing studies indicate that lung cancer has a higher prevalence, is diagnosed at more advanced stages, and carries a higher mortality among incarcerated individuals compared to non-incarcerated individuals. Although lung cancer screening is recommended based on eligibility criteria for the general population, there is a paucity of data on how screening is implemented in carceral settings, and the existing studies suggest that even eligible individuals with significant smoking history often do not undergo lung cancer screening. Furthermore, the literature provides minimal insight into lung cancer treatment for incarcerated patients.”

Experts Call for Expanded Lung Cancer Screening Eligibility Criteria
“Key Takeaways: Technological advances and multidisciplinary collaboration are essential for improving lung cancer screening and treatment strategies. Screening guidelines vary, with some models considering factors beyond smoking history, such as family history and personal cancer history.”

Radiologists, rad oncologists and thoracic surgeons rail against lung cancer screening misinformation
“Radiologists, radiation oncologists and thoracic surgeons are speaking out against lung cancer screening misinformation, spread through recently published scientific papers. Medical societies representing all three specialties issued a joint statement on Tuesday, criticizing studies claiming such scans pose potential risk of downstream complications, false positives, and dangerous radiation harm. They contend that many of these investigations are based on “substantial methodological flaws that contribute to the propagation of misinformation.””

Pain Intensity Drives Catastrophizing in Early-Stage Lung Cancer Recovery After Surgery
“For patients recovering from lung cancer surgery, pain is more than a symptom to be measured and managed because thoughts, emotions, and support systems can strongly influence how pain is perceived. New research highlights the prevalence of pain catastrophizing during the postoperative recovery period, underscoring the psychologic and social factors that shape the pain experiences of patients after surgery.”

Drug-Induced Pneumonitis: The Risk Behind New Cancer Therapies
“Advances in lung cancer treatment have changed survival in ways that were unimaginable even a decade ago. Targeted drugs, immunotherapies, and emerging antibody—drug conjugates are helping many patients live longer—and live well. But these gains may come with risks, including one called drug-induced pneumonitis, an inflammatory reaction in the lungs that ranges from mild to life-threatening.”

For lung cancer patients, smoking history may help pinpoint best treatment
“Detailed information about the current and former smoking habits of patients with non-small cell lung cancer (NSCLC) can shed light on the best way to treat them—whether with a combination of chemotherapy and immunotherapy, or with immunotherapy alone, according to new research from Harvard T.H. Chan School of Public Health.”

A study analyses which lung cancer subtypes are associated with different air pollutants
“A study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by “la Caixa” Foundation, in collaboration with the American Cancer Society (ACS), analysed the relationship between different air pollutants and the main subtypes of lung cancer. The results were published in Environmental Pollution.”

Newly discovered survival pathway explains stubborn EGFR-driven lung cancers
“Scientists from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified why certain lung cancer cells become highly resistant to treatment after developing mutations in a key gene called EGFR (epidermal growth factor receptor). In a study published in Science Advances, the researchers revealed a previously unknown survival mechanism and demonstrated that disrupting it can shrink tumors in laboratory models.”

Firmonertinib Demonstrates Promise in EGFR+ Advanced/Metastatic NSCLC
“Double-dose firmonertinib yielded promising efficacy and a manageable safety profile in a small cohort of patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) harboring EGFR L858R mutations, according to data from the phase 2 FIRM study (ChiCTR2200060897) published in Nature Communications.”