Diabetes drug appears to fight lung cancer — but only in overweight or obese patients
“Research conducted at Roswell Park Comprehensive Cancer Center has revealed that metformin also appears to fight lung cancer — but only in overweight or obese patients. Further, recent findings have led investigators to wonder whether it might also have the potential to prevent lung cancer or to be combined with other therapies to treat the disease more effectively.”
AI in Oncology: Opportunities and Challenges for NSCLC
“Ryan Nguyen, DO, physician and researcher at the University of Illinois Chicago (UIC), emphasizes the need for personalized care in managing non–small cell lung cancer (NSCLC), considering patients’ unique life circumstances, comorbidities, and treatment goals to optimize quality of life. He also discusses the potential of artificial intelligence (AI) in cancer care, highlighting its promise in aiding complex decisions while cautioning against its limitations, such as high rates of unsupported recommendations, and stresses the importance of rigorous validation to ensure patient safety.”
Researchers reveal why the lung is a frequent site of cancer metastasis
“More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells?
Prevent Lung Cancer by Testing Your Home for Radon
“WASHINGTON — In January, the EPA recognizes National Radon Action Month and encourages Americans to test their homes for radon. Radon is an odorless, colorless, naturally occurring radioactive gas that, when left unaddressed, can build up inside a home. Over time, exposure to radon can cause lung cancer. The only way to know if your home has high levels of radon is to test for it.”
For People With Rheumatoid Arthritis, Lung Cancer is Something to Worry About
“A study of Veterans Health Administration patients with rheumatoid arthritis (RA) confirmed other research showing that RA is associated with an increased risk of lung cancer and death from the death, especially among those with RA and interstitial lung disease. Corresponding author Bryant R. England, M.D., Ph.D., of the Department of Veterans Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center and his colleagues, found that RA was associated with 58% greater risk of getting lung cancer compared with not having RA and that the increased risk was similar among those who never smoked. The lung cancer risk was three times among those with RA and interstitial lung disease, according to the results reported by England and his colleagues in the December 2024 issue of the journal Arthritis & Rheumatology.”
FDA Accepts New Drug Application For Taletrectinib in ROS1+ NSCLC
“Key Takeaways: Taletrectinib’s NDA is based on phase 2 TRUST-I and TRUST-II trials, showing significant efficacy in ROS1-positive NSCLC. The trials reported tumor shrinkage in 89% of TKI-naive and 56% of TKI-pretreated patients, with prolonged progression-free survival.”
Combining Liquid and Tissue Biopsies for Better Lung Cancer Care
“Edgardo S. Santos, MD, FACP, FASCO, discussed the barriers to precision medicine in lung cancer treatment, including patient concerns about technology understanding and insurance coverage, as well as the reliance on traditional tissue biopsies, emphasizing the benefits of combining liquid and tissue biopsies to improve treatment outcomes and clinical trial eligibility.”
