Detailing the Potential Benefit of Intratumoral Therapies in Lung Cancer
“Key Takeaways: JNJ-1900 enhances radiation therapy effects while minimizing damage to healthy lung tissue, offering a promising approach for lung cancer treatment. Intratumoral therapies can reduce early treatment toxicity by delivering high concentrations of therapy directly into tumors.”
Targeted Chemo Improves Survival in Early-Stage Lung Cancer
“Key Takeaways: The AIM-HIGH trial showed significant DFS improvement in high-risk stage 1a to 2a nonsquamous NSCLC patients receiving adjuvant chemotherapy. At 24 months, 96% of chemotherapy patients were alive without disease progression, compared to 79% in the observation group.”
RET Inhibitor Rechallenge Demonstrates Activity in Previously Treated NSCLC
“Key Takeaways: Rechallenging with a different first-generation RET inhibitor showed clinical activity in RET-rearranged NSCLC patients after discontinuation due to toxicity. Patients rechallenged after toxicity had a higher objective response rate and longer progression-free survival compared to those rechallenged after disease progression.”
Pre-Op Osimertinib in Lung Cancer Leads to More Major Pathologic Responses
“CHICAGO — Neoadjuvant osimertinib (Tagrisso) with or without chemotherapy significantly increased major pathologic response (MPR) rates compared with chemotherapy alone in resectable EGFR-mutant non-small cell lung cancer (NSCLC), primary analysis of the phase III NeoADAURA trial showed.”
Curiosity and Compassion Propel Lung Cancer Pioneer Ramalingam to TIME100 Health 2025 List
“As a resident in internal medicine in the early 1990s—during a time when cancer therapies were scarce—one patient with lung cancer changed the narrative and career trajectory for Suresh S. Ramalingam, MD, FACP, FASCO, who has since worked tirelessly to propel research in this field.”
WVU Cancer Institute patient credits LUCAS for early detection followed by lifesaving treatment
“BRIDGEPORT, W.Va. – It took a rolling billboard to quiet a nagging voice Lewis County resident Penny Cooley just couldn’t shake for years. “It’s always been in the back of my mind,” the WVU Cancer Institute patient said. “Because everybody on my father’s side has died of cancer, and I smoked 21 years.””
Socazolimab Exhibits Overall Survival Benefit Vs Placebo in ES-SCLC
“Socazolimab (ZKAB001) exhibited a statistically significant overall survival (OS) benefit vs placebo when added to chemotherapy containing carboplatin and etoposide as a first-line treatment for patients with extensive-stage small cell lung cancer (ES-SCLC), according to results from a phase 3 trial (NCT04878016) published in Signal Transduction and Targeted Therapy.”
Tarlatamab Significantly Improves Survival in Patients With Small Cell Lung Cancer Post-Progression
“Key Takeaways: Tarlatamab significantly improved overall survival and progression-free survival compared to chemotherapy in SCLC patients post-platinum-based treatment. The phase 3 DeLLphi-304 trial highlighted tarlatamab’s efficacy, with reduced cancer-related symptoms and fewer severe adverse events.”
Twice Daily, Hyperfractionated Thoracic Radiotherapy Effective at 60 Gy in SCLC
“Thoracic radiotherapy twice daily at a dose of 60 Gy in 40 fractions prolonged survival and was well tolerated compared with a dose of 45 Gy in 30 fractions in patients with limited-stage small cell lung cancer (SCLC), according to a phase 2 trial (NCT02041845) published in the Journal of Thoracic Oncology.”
Roche’s Tecentriq combined with lurbinectedin shows significant survival benefit in extensive-stage small cell lung cancer
“46% reduction in the risk of disease progression or death, and 27% reduction in the risk of death, in an aggressive cancer type with limited survival and few treatment options. First Phase III study in ES-SCLC first-line maintenance to demonstrate clinically meaningful improvements in both progression-free and overall survival.”
Video:
Future of Thoracic Care Is Identifying Lung Cancer Early: Samir Shah, MD, MMM, FACR
“Samir Shah, MD, MMM, FACR, spoke about his collaboration with University Hospitals (UH) Cleveland to incorporate more artificial intelligence (AI) tools that could help identify early nodules of lung cancer. The future of thoracic care could rely on these tools to help improve prognosis in lung cancer.”
