Neoadjuvant Immunotherapy Shows Promise in Limited-Stage SCLC
“Key Takeaways: Neoadjuvant chemoimmunotherapy in LS-SCLC shows high pCR and MPR rates, indicating promising efficacy before surgery. The meta-analysis found a 95% R0 surgical resection rate, with no perioperative deaths reported.”
Breakthrough lung cancer therapy targets tumors with precision nanobody
“A research team led by Dr. Juyeon Jung at the Bio-Nano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), has developed a nanobody-based technology that can precisely identify and attack only lung cancer cells, opening new possibilities for cancer therapy. This breakthrough addresses the limitations of conventional chemotherapy by reducing harmful side effects while maximizing cancer cell-killing efficiency. In particular, it shows remarkable therapeutic potential for lung adenocarcinoma, a subtype of non-small cell lung cancer (NSCLC).”
Firefighters have higher risk for death from skin, lung, kidney cancers
“Key takeaways: Firefighters had a significantly higher risk for death from skin cancer than career professionals. Long-term follow-up suggests firefighters have significant risk for lung cancer mortality, too.”
Markey patient cancer-free after same-day lung cancer diagnosis and treatment
“LEXINGTON, Ky. (Aug. 14, 2025) — Last year, Lisa Buede made the decision to get screened for lung cancer, knowing she was eligible due to her smoking history: The 59-year-old Lexington resident had been a smoker since she was 14 years old. When the results of the screening revealed a tumor, Buede’s pulmonologist referred her to the University of Kentucky Markey Cancer Center. She would need a biopsy to determine if the nodule in her lung was cancer — and if it was, surgery to remove the mass. Under the care of UK Markey Cancer Center thoracic surgeon Shari Meyerson, M.D., Buede underwent both procedures in the same day.”
The Variability of Data and Importance of Personalized Lung Cancer Care
“Key Takeaways: Personalized patient-oncologist discussions are crucial, as overall data may not reflect individual experiences and needs. Patients should ask about realistic best and worst-case scenarios, expected side effects, and how treatments align with personal decision-making.”
Lung Cancer in Never-Smokers: Mutational Processes Affect Genomic Landscape
“Lung cancer in never-smokers (LCINS) living in areas with high air pollution is associated with a greater prevalence of TP53 mutations, shorter telomeres, and heightened mutagenesis, particularly associated with signatures SBS4 and SBS5. These were among study findings published in Nature.”
Lung cancer screening experiences among patients with a smoking history and primary care providers: a qualitative study
“Conclusions: LCS is well tolerated by patients and valued by providers. To increase LCS knowledge and uptake, systems changes are needed to facilitate shared decision-making conversations, simplify the referral process, and provide care navigation to increase patient logistical barriers to uptake.”
Ifinatamab Deruxtecan Granted Breakthrough Therapy Designation by U.S. FDA for Patients with Pretreated Extensive-Stage Small Cell Lung Cancer
“BASKING RIDGE, NJ AND RAHWAY, NJ, – Ifinatamab deruxtecan (I-DXd) has been granted Breakthrough Therapy Designation (BTD) by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with extensive-stage small cell lung cancer with disease progression on or after platinum-based chemotherapy.”
A New Reality for Terminal Cancer: Longer Lives, With Chronic Uncertainty
“Gwen Orilio didn’t know how long she had to live after her stage-four lung cancer diagnosis. The disease had already infiltrated her eye, so the 31-year-old didn’t bother opening a retirement account. Ten years later, Orilio is still alive. And she still has metastatic cancer.”
Graphene-based biosensor to support new lung cancer screening test
“HydroGraph, a Canadian producer of ultra-pure graphene, has announced a partnership with Hawkeye Bio and Ease Healthcare to support the development of a new blood test for the early detection of lung cancer. The test, known as the Lung Enzyme Activity Profile (LEAP), is a non-invasive and radiation-free diagnostic designed to identify early-stage lung cancer across all subtypes. It has shown a 99.8% negative predictive value in trials, indicating strong potential for ruling out disease in high-risk groups such as older smokers, firefighters, military personnel and first responders.”
