The quality of patient decision aids for lung cancer screening: Results from an environmental scan
“Shared decision making is recommended for lung cancer screening (LCS) by professional organizations and payers. Patient decision aids can be used to support shared decision making, but they need to meet quality standards to minimize the potential for biased and poorly informed patient decisions.”
How Cancer Changed a Patient’s Perspective on Strength and Healing
“Key Takeaways: Clara Mae Cirk’s cancer diagnosis has profoundly tested her mental resilience, prompting a reevaluation of personal strength and self-care priorities. Her diagnosis led to a shift away from corporate ambitions, allowing her to focus on healing and personal well-being.”
TT125-802 Earns FDA Fast Track Designations for EGFR+ and KRAS G12C+ Advanced NSCLC
“Key Takeaways: TT125-802 targets transcriptional pathways in NSCLC with EGFR and KRAS mutations, addressing treatment resistance and progression. Phase 1 trial results show TT125-802 provides clinical benefits and is well tolerated, with most adverse effects being mild.”
Neoadjuvant Immunotherapy Plus Chemotherapy Shows Promise in LS-SCLC
“Key Takeaways: Neoadjuvant immunotherapy plus chemotherapy shows a 35% pathological complete response rate and 49% major pathological response rate in LS-SCLC. Most patients achieved R0 surgical resection, with a 44% rate of treatment-related serious adverse events, indicating acceptable toxicity.”
Real-world costs, treatment patterns, and clinical outcomes associated with treatments for advanced anaplastic lymphoma kinase-positive non-small cell lung cancer
“Background: Alectinib, brigatinib, and lorlatinib are all preferred first-line (1L) therapies for anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in National Comprehensive Cancer Network (NCCN) guidelines. Although clinical trials have demonstrated their efficacy, real-world evidence on treatment patterns, costs, and outcomes may help differentiate these therapies and inform optimal 1L treatment selection in the absence of head-to-head comparisons.”
Iza-Bren Receives FDA Breakthrough Therapy Designation for EGFR-Mutated NSCLC
“Key Takeaways: Iza-bren targets EGFR and HER3, reducing cancer cell proliferation and survival, and is designed for NSCLC with specific EGFR mutations. The FDA’s breakthrough therapy designation is based on data from three ongoing clinical trials assessing iza-bren’s safety and efficacy.”
LUNGevity Foundation Pays Tribute to Lung Cancer Advocate Bonnie J. Addario
““We are deeply saddened by the passing of Bonnie J. Addario, whose warmth and boundless energy touched countless lives in the lung cancer community, including our own. We are profoundly grateful for her leadership, her vision, and her enduring spirit of championing the patient.
Bonnie, a lung cancer survivor and pioneering advocate, transformed the landscape of lung cancer research and patient support and was a valued partner to LUNGevity and the entire lung cancer community. With tireless dedication, she united patients, researchers, clinicians, fellow advocacy groups and industry partners, always centering patient needs and building bridges across the community.
Bonnie’s impact extends far beyond the organizations she founded; it lives on in the collaborative spirit she championed and the countless lives she touched.
The lung cancer community will forever be shaped by her trailblazing work, her generosity of spirit, and her unwavering dedication to others. Our heartfelt condolences go out to Tony, Danielle, Andrea, and her entire family.
Rest in Peace Bonnie. We are forever grateful for you.”
