New Summit data clouds approval pathway in lung cancer
“A combination of ivonescimab and chemotherapy didn’t extend survival over chemo alone in a global trial, missing a key goal often emphasized by regulators.”
First-in-human trial shows promising results for antibody-drug conjugate in relapsed small cell lung cancer
“A first-in-human Phase I study of SHR-4849 (IDE849), a Delta-like ligand 3 (DLL3)-directed antibody-drug conjugate (ADC), demonstrated manageable safety and early signs of anti-tumor activity in patients with relapsed small cell lung cancer (SCLC).”
Dispelling Myths and Raising Awareness of Lung Cancer Risk
“Leah Phillips, co-founder of the Young Lung Cancer Initiative, had her life profoundly altered when she was diagnosed with stage IV lung cancer driven by an EGFR exon 19 mutation. A never-smoker, Leah had no traditional risk factors and initially believed her diagnosis must have been a mistake. This experience has fueled her advocacy, as she seeks to dispel the misconception that lung cancer only affects smokers or older adults.”
Study validates AI lung cancer risk model Sybil in predominantly Black population at urban safety-net hospital
“A new study presented at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC) validates the use of Sybil, a deep learning artificial intelligence model, for predicting future lung cancer risk in a predominantly Black population.”
Data published in The New England Journal of Medicine demonstrate RYBREVANT® (amivantamab-vmjw) plus LAZCLUZE® (lazertinib) is re-setting survival expectations in first-line EGFR-mutated lung cancer
“RARITAN, N.J., Sept. 7, 2025 /PR Newswire/ – Johnson & Johnson (NYSE: JNJ) today announced The New England Journal of Medicine (NEJM) published results from the Phase 3 MARIPOSA study, which showed RYBREVANT® (amivantamab-vmjw) plus LAZCLUZE® (lazertinib) demonstrated a statistically significant and clinically meaningful overall survival (OS) improvement for patients with previously untreated (first-line) locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions (ex19del) or L858R substitution mutations.”
FDA Grants Breakthrough Therapy Designation to Olomorasib With Pembrolizumab for NSCLC
“Key Takeaways: Olomorasib, combined with pembrolizumab, targets KRAS G12C-mutant NSCLC, addressing unmet needs in first-line treatment with high PD-L1 expression. NSCLC accounts for 80%-85% of lung cancer cases, with KRAS G12C mutations present in about 13% of patients.”
Millennial Woman Spends 3 Months Coughing—Then Gets Devastating Diagnosis
“A woman who thought that her health problems were caused by stress and anxiety has revealed how the symptoms she documented online ultimately led to a shocking diagnosis at just 28 years old. Aurora Lucas, now 32, shared her story on TikTok (@aurorainnalucas), gathering nearly half a million views.”
FDA Grants Breakthrough Therapy Designation to Zongertinib (HERNEXEOS) for First-Line Treatment of HER2-Mutant Advanced NSCLC
“On September 3, 2025, Boehringer Ingelheim announced that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation to Zongertinib as a potential first-line treatment for adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) carrying HER2 (ERBB2) tyrosine kinase domain activating mutations.”
