Actinium Pharmaceuticals to Unveil the Multi-Tumor Potential of ATNM-400, a First-in-Class Actinium-225 Radiotherapy, with Data in Non-Small Cell Lung Cancer at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
“ATNM-400 is advancing as a first-in-class, multi-tumor Actinium-225 radiotherapy candidate with activity across prostate and lung cancers, two of the largest cancer indications globally. New preclinical findings demonstrate ATNM-400 overcomes resistance to the EGFR inhibitor osimertinib in EGFR-mutated NSCLC, addressing a major unmet clinical need”
New ‘Google maps’ approach to revolutionise lung cancer treatment
“Key points: Researchers have developed a way to predict how the most common form of lung cancer will respond to different therapies. Non-small cell lung cancer was mapped cell-by-cell using spatial biology and AI, taking the guess work out of drug treatment. The same approach could be used to inform treatments for other malignancies like melanoma, head and neck, and bladder cancer.”
Basal cells drive small cell lung cancer plasticity
“Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy. The cell of origin is thought to be the pulmonary neuroendocrine cell, but pulmonary neuroendocrine cells fail to generate an aggressive form of the disease that is driven by tuft-like cells, suggesting the involvement of other cell types.”
30+ patient groups warn: Catastrophic coverage losses without Congressional action
“Today 33 non-partisan, non-profit patient advocacy organizations issued the following statement in response to Congress’s failure to renew the expiring enhanced premium tax credits (eAPTCs) before insurance companies issued their premium increase notices for the 2026 plan year. Congressional Budget Office estimates suggest that 1.5 million people will lose health coverage if Congress delays acting until December.”
Scientists need your toenails
“Donating blood, plasma, organs, and even full bodies saves countless lives every year. But toenail clippings could also become a life-saving body part with a new pilot study from the University of Calgary in Canada. The team is soliciting toenail donations (sorry, only from Canadians) to study a type of cancer that arises far from our feet–lung cancer.”
Early detection of non-small cell lung cancer: an electronic health record data-driven approach
“Conclusions: This study identified EHR-derived features which are predictive of early NSCLC diagnosis. The developed risk prediction model exhibits superior performance for early detection of NSCLC compared to a baseline model that only relies on demographic and smoking information, demonstrating the potential of incorporating EHR-derived features for personalized cancer screening recommendations and early detection.”
Study Shows Mediastinal LND Not Recommended in GGO-Dominant Lung Cancer
“Key Takeaways: The trial showed no lymph node metastasis in either arm, questioning the necessity of systematic LND in GGO-dominant lung adenocarcinoma. Patients in the no LND arm had shorter surgery duration, less blood loss, and reduced postoperative hospital stay compared to the systematic LND arm.”
Inflammation Biomarkers Signal High Lung Tumor Mutations
“In an innovative breakthrough study published in BMC Cancer, researchers have unveiled that systemic inflammation biomarkers may hold the key to identifying high tumor mutation burden (TMB) in lung adenocarcinoma patients. This revelation stands to revolutionize the way clinicians approach the assessment of TMB, a crucial biomarker for immunotherapy efficacy in non-small cell lung cancer (NSCLC).”
Federal Housing Assistance Linked to Earlier Cancer Diagnosis in Older Adults
“A new study led by researchers from the Johns Hopkins Bloomberg School of Public Health found that older adults receiving federal housing assistance were on average diagnosed at earlier stages with three common cancers—colon, breast, and non-small cell lung—compared to peer cancer patients who were not receiving assistance. The findings suggest that federal housing programs may provide supports that help improve cancer diagnosis. Early cancer diagnosis is key to better prognoses and has saved millions of lives.”
Innovative inhalable dry powder: nanoparticles loaded with Crizotinib for targeted lung cancer therapy
“In vitro studies indicated that the polymeric nanoparticles exhibited greater anticancer activity compared to free Crizotinib. Additional characterization using techniques like XRD, DSC, FTIR, and SEM confirmed that the polymeric nanoparticle formulation has promising physicochemical properties, suggesting it could enhance local drug delivery and efficacy in lung cancer treatment while potentially reducing systemic toxicity.”
