“Scientists have found a way to supercharge lung cancer treatment by transplanting healthy mitochondria into tumors, which both boosts immune response and makes chemotherapy far more effective. By combining this novel method with cisplatin, researchers reversed harmful tumor metabolism and empowered immune cells to fight back, all without added toxicity.”
New Research aimed at Predicting Which Lung Cancer Patients will respond to Immunotherapy, Earns a $200,000 Grant from LCFA and IASLC
“Los Angeles, CA, Aug. 01, 2025 (GLOBE NEWSWIRE) — A transformative breakthrough in lung cancer research is set to reshape how doctors treat certain forms of lung cancer and how quickly they’re able to adopt an effective treatment plan. The “MANAscore,” developed by Dr. Zhen Zeng at Johns Hopkins University, is a new computational approach that enables the identification of tumor-fighting T-cells at an unprecedented scale, potentially helping oncologists predict which patients will benefit from life-saving immunotherapy before treatment begins.”
Dr Florez on the Importance of Establishing Consensus Within the Evolving Lung Cancer Treatment Landscape
“Narjust Florez, MD, associate director of the Cancer Care Equity Program and a thoracic medical oncologist at Dana-Farber Cancer Institute; as well as a faculty member at Harvard Medical School, discussed the importance of establishing expert consensus in the evolving lung cancer treatment paradigm in 2025. She emphasized that the Bridging the Gaps in Lung Cancer meeting, now in its third year, is uniquely structured to identify and address clinical uncertainties in real time as new data emerge.”
Large-scale gene analysis identifies new biomarkers and drug targets for lung adenocarcinoma
“By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer.”
Update on Drug-Induced Pneumonitis in Lung Cancer
“A collaborative, multidisciplinary approach is essential to optimize patient safety and outcomes in lung cancer care. In this manuscript we describe approaches to pre-treatment assessment, evaluation of suspected pneumonitis, and management of pneumonitis on a drug-specific basis. We emphasize emerging data and drug classes, while also highlighting remaining areas of uncertainty.”
The mutagenic forces shaping the genomes of lung cancer in never smokers
“A positive dose–response effect was observed with air-pollution levels, correlating with both a decrease in telomere length and an increase in somatic mutations, mainly attributed to signatures SBS4 and SBS5. Our results elucidate the diversity of mutational processes shaping the genomic landscape of lung cancer in never smokers.”
New 3D bioprinted lung tissue could transform respiratory research
“Researchers at UBC Okanagan have developed a 3D bio-printed model that replicates the complexity of natural lung tissue. This development, detailed in Biotechnology and Bioengineering, could change how scientists’ study respiratory diseases and develop new therapeutic options.”
