Alectinib Approved as an Adjuvant Treatment for Lung Cancer
“Some people with non-small cell lung cancer (NSCLC) that can be removed surgically should be treated afterward with the targeted therapy alectinib (Alecensa), results from a large clinical trial suggest. Participants in the ALINA trial had tumors with changes in the ALK gene, often called ALK-positive lung cancer. Those treated with alectinib after surgery lived longer without their cancer coming back than those treated with chemotherapy after surgery, the current standard treatment.”
Lifileucel Yields Responses in Metastatic Non–Small Cell Lung Cancer
“Treatment with the autologous tumor-infiltrating lymphocyte (TIL) cell therapy lifileucel (Amtagvi) produced responses in a small cohort of patients with heavily pretreated metastatic non–small cell lung cancer (NSCLC), including those with different mutational burdens and PD-L1 expression, according to findings from the phase 2 IOV-COM-202 study (NCT03645928) published in Cancer Discovery.”
Why do non-smoking Asian women have high rates of lung cancer? A UCSF study hopes to find out.
“A Bay Area-based study finds that 80% of Asian American women with lung cancer never smoked and researchers are trying to figure out why.”
Nivolumab/Chemoradiotherapy Regimen Misses PFS End Point in Unresectable, Locally Advanced NSCLC
“Treatment with nivolumab (Opdivo) plus concurrent chemoradiotherapy, followed by the combination of nivolumab and ipilimumab (Yervoy) did not improve progression-free survival (PFS) vs chemoradiotherapy followed by durvalumab (Imfinzi) in patients with unresectable, locally advanced, stage III non–small cell lung cancer (NSCLC), missing the primary end point of the phase 3 CheckMate73L trial (NCT04026412).”
A blood test to help detect lung cancer? New test offered at OSF Healthcare part of trend in medicine
“CHICAGO — Julie Harris had never been tested for lung cancer. A low-dose CT scan, the only recommended screening for adults at risk of developing lung cancer, was not something she’d ever found time to do. But when her primary care doctor recently suggested a new blood test to help look for signs of the disease, Harris was intrigued. She had her blood drawn the same day, in the same building as her doctor’s appointment.”
How the Immune System Affects Drug Response in Lung Cancer Patients
“Why do some lung cancer patients respond better to the types of drugs known as tyrosine kinase inhibitors? It may have to do with those patients’ own immune systems. That’s the hypothesis being tested by University of Colorado Cancer Center member Lynn Heasley, PhD, who recently received a Merit Review Award renewal from the U.S. Department of Veterans Affairs (VA) to study the role of the immune system in patients with lung adenocarcinoma who are treated with tyrosine kinase inhibitors (TKIs).”
FDA Grants Fast Track Designation to SNB-101 in Small Cell Lung Cancer
“The FDA has granted fast track designation to SNB-101, an anti-cancer agent derived from SN-38 as nanoparticles, as a treatment for patients with small cell lung cancer (SCLC), according to a press release from the developers, SN Bioscience.”
Exacerbations Predict Poor Outcomes in Lung Cancer Patients With Idiopathic Interstitial Pneumonia
“TAKEAWAY: The overall median survival rate for the entire study population was 9.9 months; patients with acute exacerbations had significantly worse survival than those without exacerbations at all time points (hazard ratios of 5.191, 2.351, 2.416, and 2.521 at 30, 60, 90, and 120 days, respectively). The incidence of acute exacerbation was greater in patients with non–small cell lung cancer than in those with small cell lung cancer (12.6% vs 4.2%; odds ratio, 3.316). Treatment regimens specifically for non–small cell lung cancer were significant independent predictors of acute exacerbations triggered by the therapies in a multivariate analysis (odds ratio, 3.316; P = .016).”
Study seeks to evaluate military exposures on veterans’ lung cancer risk
“Recruitment has begun for a national, multisite Department of Veterans Affairs (VA) study that seeks to expand lung cancer screening eligibility, reduce the time to lung cancer diagnosis, and increase veteran engagement.”
New study links gas stoves to child asthma, lung cancer and death
“A study led by Stanford researchers says nitrogen dioxide exposure from gas stoves could be responsible for an estimated 19,000 deaths per year.”
The Importance of Telling Your Cancer Story Honestly
“With this past April being proclaimed by the White House as National Cancer Prevention and Early Detection Month and with DNA Day on the 25th, it seemed like the perfect time to share my late wife’s hereditary cancer story with the White House. The White House has a “Share Your Story” button on the Cancer Moonshot page and I was going to make sure my wife’s cancer story and how her cancer could have been prevented was shared.”
Study Identifies Disparities in End-of-Life Care for Lung Cancer Patients
“Patients with lung cancer who were Asian/Pacific Islander, Black or Hispanic experienced a higher intensity of end-of-life care compared to white patients, according to a Northwestern Medicine population-based analysis published in the Journal of Clinical Oncology.”
Video:
NU surgeons perform 1st double-lung transplant on Chicago police officer who had lung cancer, COVID
Maine lung cancer rates above national average, experts urge annual screenings
New Hope on the Horizon for Patients With SCLC
“Ariel Lopez-Chavez, MD, medical oncologist, director of precision medicine and developmental therapeutics at Allegheny Health Network Cancer Institute, discusses ongoing research in the small cell lung cancer (SCLC) space.”
